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Category: Bio Sciences & Technology

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Prevent Blindness Ohio Recognizes Dr. Rafat Ansari

Dr. Rafat Ansari (Bio Sciences & Technology Branch) was recognized at the Vision Research Scientific Forum for his voluntary service on the selection committee of “Young Investigator Student Fellowship Awards for Female Scholars in Vision Research” held in Columbus, Ohio, on November 18, 2009.

The event was hosted by Prevent Blindness Ohio (PBO). The Fellowship Program is designed to provide support for outstanding female scientists (MD, OD, and PhD students) committed to pursuing biomedical, behavioral, and clinical research careers to prevent blindness and preserve sight.

NASA Glenn Cataracts Research Receives Enthusiastic Review

A major international publication Review of Ophthalmology in its October 2009 issue published a review article, “Cracking the Cataract Code: New Technology, New Hope” written by Senior Editor Christopher Kent. The article (pages 80-87) discusses the NASA Glenn Research Center-developed dynamic light scattering (DLS) technology, the clinical trials conducted at the National Eye Institute of the NIH, and current and future studies.

Distinguished Congressional Recognition Given

Dr. Bilal Mark McDowell Bomani (Bio Sciences & Technology Branch) was recognized on August 12, 2009, by the Honorable Marcia L. Fudge, U.S. House of Representatives, and 11th Congressional District of Ohio. The letter from Congresswoman Fudge read as follows:

“Dear Dr. Bilal Bomani, On behalf of myself and the entire 11th Congressional District, I would like to recognize you for your outstanding achievements, including your scientific and engineering research. Dr. Bomani, you are not only improving Cleveland, but the entire world. You will be recognized at my first State of the District Address, in which I will give an update on positive changes to the Greater Cleveland Area, including information on upcoming legislative initiatives.”


NEI-NASA Team Up for Early Cataract Detection Tool

A front page article published in the NIH Catalyst describes in detail how the NASA GRC technology developed by Dr. Rafat Ansari led to breakthrough clinical research. Author is Allyson T. Collins, Science Writer/Editor, National Eye Institute, National Institutes of Health.

Read the story in the March-April 2009 edition of the NIH Catalyst (PDF).

“Distal Fingertip Injuries in Astronauts” Paper Published in Optical Diagnostics and Sensing

“A Non-Invasive Miniaturized-Wireless Laser-Doppler Fiber-Optic Sensor for Understanding Distal Fingertip Injuries in Astronauts”; authored by Rafat R. Ansari, PhD, Jeffrey A. Jones, MD, Luca Pollonin, PhD, Mikael Rodríguez, Roedolph Opperman, and Jason Hochstein; was published in Optical Diagnostics and Sensing IX, edited by Gerard L. Coté, Proc. of SPIE Vol. 7186, March 2009.

During extra-vehicular activities (EVAs), or space walks astronauts overuse their fingertips under pressure inside the confined spaces of gloves/space-suite. The repetitive hand motion is a probable cause for discomfort and injuries to the fingertips. The paper describes a new miniaturized wireless fiber-optic sensor that can be integrated inside the astronaut glove for non-invasive blood perfusion measurements in distal fingertips.

In this seven subject pilot study, blood perfusion measurements were performed during handgrip exercises in a hypobaric chamber simulating the use of space tools. This work is now translating into a larger astronaut population study in collaboration with JSC’s EVA Physiology, Systems, and Performance Project, and Neutral Buoyancy Laboratory.

Federal Laboratory Consortium’s Newsletter Features GRC Researcher

The nationally distributed Federal Laboratory Consortium’s January/February 2009 NewsLink Newsletter (PDF) featured a multipage article entitled, “NASA Study Investigates Stress in Pilots.” The article featured the research being performed by the Bio Science and Technology branch’s Angela Harrivel and Terri McKay in pilot cognition using non-intrusive diagnostics including functional near-infrared spectroscopy. The project is supported by ARMD/Integrated Intelligent Flight Deck.

From Outer Space to the Eye Clinic: New Cataract Early Detection Technique

Patients and Astronauts Benefit from NEI-NASA Collaboration

A compact fiber-optic probe developed for the space program has now proven valuable for patients in the clinic as the first non-invasive early detection device for cataracts, the leading cause of vision loss worldwide.

Researchers from the National Eye Institute (NEI), part of the National Institutes of Health, and the National Aeronautics and Space Administration (NASA) collaborated to develop a simple, safe eye test for measuring a protein related to cataract formation. If subtle protein changes can be detected before a cataract develops, people may be able to reduce their cataract risk by making simple lifestyle changes, such as decreasing sun exposure, quitting smoking, stopping certain medications and controlling diabetes.

“By the time the eye’s lens appears cloudy from a cataract, it is too late to reverse or medically treat this process,” said Manuel B. Datiles III, M.D., NEI medical officer and lead author of the clinical study. “This technology can detect the earliest damage to lens proteins, triggering an early warning for cataract formation and blindness.”

The new device is based on a laser light technique called dynamic light scattering (DLS). It was initially developed to analyze the growth of protein crystals in a zero-gravity space environment. NASA’s Rafat R. Ansari, Ph.D., senior scientist at the John H. Glenn Research Center and co-author of the study, brought the technology’s possible clinical applications to the attention of NEI vision researchers when he learned that his father’s cataracts were caused by changes in lens proteins.

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Editorial Review and Cover Illustration Done for Vascular Analysis Review Paper on VESGEN Software

Vascular analysis by VESGEN software was presented in a vascular imaging symposium at the International Experimental Biology Meeting in Washington, D.C. during 2007. A special issue of Anatomical Record A, “Imaging the Living Vasculature” is featuring papers based on the symposium, including the GRC review paper, “VESGEN 2D: Automated, User-Interactive Software for Quantification and Mapping of Angiogenic and Lymphangiogenic Vascular Trees and Networks.”

Several applications of VESGEN to vascular trees, networks, and tree-network composites are illustrated by disease progression in the human retina; assessment of a clinical steroid in an avian model and a murine model of human infant retinopathy of prematurity; cytokine-stimulated abnormalities of lymphangiogenesis in the avian model, and progressive development of murine and avian coronary vasculature.

A VESGEN mapping of a vascular tree was selected from all vascular images as the cover illustration, and use of the VESGEN software is described in the lead editorial paper. Coauthors include Mary Vickerman, Patricia Keith, Terri McKay, Dan Gedeon, Alan Hylton, Daniela Ribita and Patricia Parsons (NASA GRC) and six collaborators at the Cleveland Clinic and University Hospitals.

Paper Published in Archives of Ophtalmology

The National Eye Institute(NEI) of National Institute of Health (NIH) and NASA GRC clinicians/researchers (Bio Sciences & Technology Branch) published a paper, “Clinical Detection of Precataractous Lens Protein Changes Using Dynamic Light Scattering,” Datiles MB III; Ansari, RR; Suh, KI; Vitale S; Reed GF; Zigler JS Jr; Ferris FL III, Arch. Ophthalmol. 126(12):1687-1693. 2008.

A new non-invasive eye test clinically and non-invasively detects the damage caused by oxidative stress to a patient’s eye (and perhaps the body) by measuring the amount of alpha crystallin lost over time. One can now measure the amount of alpha crystalline “reserve” of the eye, similar to creatinine clearance allowing clinicians to track kidney functional reserve. This is an early alarm system which if unchecked will lead to cataract formation and blindness.

ASA astronauts will benefit from this new, safe, and non- invasive eye test to assess their exposure to unhealthy environmental conditions or practices (e.g., radiation, nutrition, hyperbaric conditions) leading to increased oxidative stress and cataract formation. This study was conducted under a NASA – NEI Interagency Agreement.

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